PEARLS (created by the Primary Healthcare Field based in New Zealand and funded by the New Zealand Ministry of Health and New Zealand Doctor)
760: Does calcium supplementation improve pregnancy and infant outcomes?
759: Does Galantamine benefit people with dementia due to Alzheimer’s and mild cognitive dementia?
758: What is the effect of lower blood pressure targets for people with chronic renal disease?
757: Should family-based care be used for people with schizophrenia?
756: What is the best way to treat an ankle fracture?
755: Can pharmacological interventions help palliative care patients suffering from pruritus?
754: Do SSRI's help premenstrual syndrome and premenstrual dysphoric disorder?
753: Do educational and psychological interventions help those managing atopic eczema?
752: Is TENS and effective treatment for primary dysmenorrhoea?
751: Can CBT help older people with anxiety disorders?
750: Can additional time outdoors prevent or slow the progression of myopia in children?
749: Are there effective non-surgical interventions for osteoarthritis of the big toe?
748: Are there any effective treatments for postburn itch?
747:
745: Which type of physical exercise ben
743: Can psychological therapies effectively treat depression in older adults in assisted living?
742: Can hospital at home avoid hospital admittance?
741: Do m-health smartphone interventions help adolescents and adults who are overweight or obese?
740: Do decision aids help people make decisions about healthcare?
739: Do cranberries help prevent UTIs?
738: Should we be taking zinc to prevent and treat the common cold?
736: Does adenoidectomy help prevent further recurrences of otitis media with effusion in children?
735: What is the best treatment for alopecia areata?
734: Is bladder training effective for treating an overactive bladder in adults?
733: Does timed intercourse increase the chances of pregnancy for couples trying to conceive?
731: Should you give paracetamol or an NSAID or both together for pain relief in acute otitis media?
730: Does the combined oral contraceptive pill help those that suffer from primary dysmenorrhoea?
729: Does endovenous ablation aid healing of venous leg ulcers?
728: Does social networking to support cardiac rehabilitation, benefit people with heart disease?
725: Do cannabis-based medicines and medical cannabis relieve pain in adults with cancer?
724: Can pharmacological interventions benefit those with an acute attack of vestibular migraine?
723: Do cranberries prevent urinary tract infections?
722: Should antidepressants be prescribed to treat depression in people with cancer?
721: Can controlling blood pressure reduce the incidence of ocular complications in people with diabetes?
720: Can exercise benefit people with pulmonary hypertension?
719: Can changing the environment prevent falls in older people?
718: Does dietary supplementation with antenatal myo-inositol prevent gestational diabetes?
717: Can Vitamin D supplementation improve asthma control?
716: Does lowered salt intake prevent or slow the progression of diabetic kidney disease?
715: Are glucocorticoids the best drug for relieving croup?
714: Is reducing blood pressure to below standard targets helpful?
713: Do corticosteroids help treat radicular and non‐radicular low back pain?
712: Do antidepressants help to treat hip and knee osteoarthritis?
711: Should you increase corticosteroids or exacerbations in chronic asthma?
710: Is acupuncture an effective treatment for overactive bladder?
709: Do mobility strategies improve patient outcomes after hip fracture?
708: Does listening to music help adults who suffer from insomnia?
707: Does physical activity benefit people with irritable bowel syndrome?
706: How effective are antiplatelet agents for the treatment of DVT's?
705: How effective are anti-IL-5 therapies for asthma?
704: Can GPs clinical judgement be used for the diagnosis of dementia?
703: Are there effective interventions to prevent falls in people with Parkinson's disease
702: Is there an effective treatment to prevent recurrent vulvovaginal candidiasis?
701: Do cannabinoids provide symptom relief for people with multiple sclerosis
699: Are oral antihistamine‐decongestant‐analgesic combinations effective against the common cold?
698: Does extra calcium help to prevent primary hypertension?
697: Is arthroscopic surgery warranted for degenerative knee disease?
696: Are inhaled corticosteroids effective for treating COVID‐19?
694: How do Calcium channel blockers compare to other drugs for the treatment of hypertension?
693: Are foot orthoses effective for treating paediatric flat feet?
692: Are rapid point of care antigen tests sufficient for diagnosing COVID-19?
691: Does actively providing information to stroke survivors and their carers improve quality of life?
690: Does phototherapy help those suffering from atopic eczema?
689: Does music therapy improve psychological and physical outcomes for people with cancer?
688: Does exercise therapy help people suffering from low back pain?
687: Can strategies delivered in primary care improve smoking cessation rates?
686: Can you improve adherence to pharmacological therapy for those with COPD?
685: Can non-drug therapies prevent lower limb muscle cramps?
684: Is Chronic non-invasive ventilation useful for chronic obstructive pulmonary disease?
683: How good is telehealth assessment for the diagnosis of dementia and mild cognitive impairment?
682: Does bisphosphonate use improve bone mineral density in children with cerebral palsy?
681: Does reducing salt intake benefit adults with chronic kidney disease?
678: Does Pharmacological treatment of Gastro-Oesophageal Reflux Disease help Asthma sufferers?
677: Is anticholinergic burden a prognostic factor for future cognitive decline in older adults?
676: What is the safest and most effective treatment for varicoceles in men affected by subfertility?
675: Do Selective serotonin re‐uptake inhibitors help men with premature ejaculation?
673: Do biologics work for sufferers of chronic rhinosinusitis?
672: Does quitting smoking improve mental Health?
671: Do skin care interventions stop infants from developing eczema and allergies?
670: Should you give cancer patients primary prophylaxis for venous thromboembolism?
669: Does acupuncture help chronic low back pain?
668: Is surgery still the best answer for basal cell carcinoma?
667: Do oropharyngeal exercises reduce sleepiness in people suffering from sleep apnoea?
666: Do electronic cigarettes help smokers quit?
665: What is the best systemic immunosuppressive treatment for eczema?
664: Treating vaginal thrush with oral or intravaginal medication: which is better?
661: Will psychological therapy be helpful for women who experience intimate partner violence?
660: Is LNG-IUS acceptable and safe for women with heavy menstrual bleeding?
659: Is withdrawal of antihypertensives in older people feasible?
658: Is Pitavastatin better than older statins for lowering lipids?
656: Indoor Salt Water Baths + UVB Light helps Chronic Psoriasis
655: Reducing Dietary Saturated Fat will reduce the risk of cardiovascular events
654: Corticosteroids for sore throats maybe beneficial but more information on harms needed
653: NSAIDS provide limited benefit to those with low back pain
652: Breathing Exercises shown to be Beneficial for Adults with Asthma
650: Text-based messaging interventions improve smoking cessation rates
649: Early rather than deferred androgen suppression therapy more beneficial for advanced prostate cancer
648: Uncertainty on Mediterranean-style diet for prevention of cardiovascular disease
647: Limited benefit for tramadol in osteoarthritis
646: Range of interventions effective for emergency contraception
645: Exercise-based cardiac rehabilitation beneficial in cardiac failure
644: No evidence for vitamin and mineral supplementation for maintenance of cognitive function in adults
643: Evidence for effectiveness of cannabis and cannabidiol on ulcerative colitis uncertain
642: Insufficient evidence for pharmacotherapies for cannabis dependence
641: Uncertainty over effectiveness of TENS for chronic pain
640: Small benefit for low-dose antibiotics to prevent recurrence of symptomatic UTI in children
639: Minimal benefits from paracetamol for the treatment of osteoarthritis of the knee or hip
638: Limited evidence for benefits of omega-6 fats for prevention of cardiovascular disease
637: Perioperative alcohol cessation intervention reduces postoperative complications
636: Limited evidence for benefits of computer-assisted techniques for diagnosing skin cancer in adults
635: No place for antibiotics for acute rhinosinusitis in adults
634: Prophylactic antibiotic therapy effective for chronic obstructive pulmonary disease
633: Limited evidence for effectiveness of relapse prevention interventions for smoking cessation
632: Patient-mediated interventions improve professional practice
631: Omega-3 fatty acids beneficial in pregnancy
630: Limited benefits from methotrexate in adults with psoriatic arthritis
629: Small benefit for low-dose antibiotics to prevent recurrence of symptomatic UTI in children
628: Combination nicotine replacement therapy more effective than single-form for smoking cessation
627: Little evidence of benefits for routine scale and polish for periodontal health
626: No evidence of benefits from H1 antihistamines for eczema
625: Exercise programs reduce falls in older people living in the community
624: General health checks unlikely to be beneficial
623: Taxane-based chemohormonal therapy effective for metastatic prostate cancer
622: School-based interventions effective in preventing multiple risk behaviours
621: Graduated compression stockings prevent postoperative deep vein thrombosis
620: Effects of cannabis on Crohn’s disease uncertain
619: Mirror therapy improves motor function after stroke
618: Limited evidence for benefits of antidepressants in dementia
617: Nurses effective as substitutes for doctors in primary care
616: Glucocorticoids effective for croup in children
614: Communication skills training beneficial for health care professionals working in cancer care
613: Limited evidence for benefit of ear drops for removal of wax
612: Antibiotics effective for prolonged wet cough in children
611: Epidural effective for pain relief in labour
610: Some benefits from donepezil in Alzheimer’s disease
609: Some benefits from induction of labour at or beyond term
608: Limited benefit from grommets for recurrent acute otitis media in children
606: Psychotherapy effective for treatment-resistant depression in adults
605: Little evidence of effectiveness of antidepressants for insomnia in adults
604: All forms of nicotine replacement therapy effective for smoking cessation
603: SSRIs beneficial for social anxiety disorder
602: Drug-eluting stents may be more effective than bare-metal stents for acute coronary syndrome
601: Vaccines have modest impact on influenza in healthy adults
600: Limited evidence for benefits of open surgery for trigger finger
599: Group behaviour therapy sessions effective for smoking cessation
598: Little or no benefits for e-learning over traditional learning
597: Lack of evidence for cannabis in adults with chronic neuropathic pain
596: Vaccines reduce influenza in the elderly
595: Screening and brief alcohol interventions effective in primary care populations
594: No evidence for cardiovascular benefits from low glycaemic index diets
593: Psychological treatments beneficial for people with epilepsy
592: Corticosteroids beneficial for adults with severe community-acquired pneumonia
591: Insufficient evidence for effectiveness of acupuncture for neuropathic pain
590: Home treatment has benefits over in-patient treatment for deep vein thrombosis
588: Exercise effective for intermittent claudication
587: Limited benefits from bisphosphonates for advanced prostate cancer
586: Limited benefits from pharmacotherapy for hypertension in people under 60
585: Clinician-targeted interventions can reduce antibiotic prescribing for ARIs
584: Gabapentin effective for some patients with chronic neuropathic pain
583: No overall health benefit from lower blood pressure targets
582: Personalised digital interventions reduce hazardous and harmful alcohol consumption
581: HPV testing more sensitive than cytology for cervical screening
580: Music therapy beneficial for depression
579: Mass media interventions effective for smoking cessation
578: Insufficient evidence of benefits from whole grain cereals in cardiovascular disease
577: Individual behavioural counselling assists quitting
576: Antioxidant vitamin and mineral supplements may be beneficial in age-related macular degeneration
575: Early supported discharge services beneficial for people with acute stroke
574: Oral antifungals effective for toenail onychomycosis
573: Proton pump inhibitors effective for functional dyspepsia
572: Music-based therapeutic interventions help depression in dementia
571: Decision aids beneficial for people facing health treatment or screening decisions
570: Probiotics beneficial for recurrent abdominal pain in childhood
569: Computer-generated reminders on paper benefit quality of care
568: Chlorhexidine mouthrinse effective short-term adjunct for dental plaque reduction
567: No evidence of benefits from oral NSAIDs for fibromyalgia
566: Tobacco cessation interventions helpful for people with substance use disorders
564: No evidence for drug treatments for recurrent abdominal pain in children
563: Little evidence of benefit for injected corticosteroids in plantar heel pain
562: Standardised packaging reduces tobacco use
561: No effective interventions for molluscum contagiosum
560: Topical analgesics effective for acute and chronic pain
559: Shared care effective for depression
558: Psychosocial interventions effective for smoking cessation in pregnancy
557: Industry sponsorship influences research outcomes
556: Breastfeeding support improves outcomes
555: Limited evidence for benefits of prophylactic drug treatment for febrile seizures
554: Moisturisers beneficial for eczema
553: Non-medical prescribers effective in management of chronic disease
552: Topical capsaicin effective for chronic neuropathic pain
551: Topical analgesics effective for acute and chronic pain
550: Psychosocial therapy of some benefit in recurrent abdominal pain in childhood
548: Need to balance benefits and risks of long-term hormone therapy in postmenopausal women
547: No evidence of benefits from stretch for the treatment and prevention of contractures
546: Limited evidence of effectiveness of analgesics in AOM in children
545: Little evidence on effective pharmacotherapies for sleep disturbances in dementia
544: Written information can reduce use of antibiotics for acute URTIs
543: Modest benefit of fibrates for primary prevention of cardiovascular disease
542: Thrombolysis and anticoagulants more effective than anticoagulants alone in acute DVT
541: Yoga beneficial for women with breast cancer
540: No evidence of benefits from corticosteroids alone in Guillain-Barre syndrome
539: Paracetamol no better than placebo for acute low back pain
538: Electronic cigarettes assist smoking cessation
537: Corticosteroids effective for Bell’s palsy
536: Speech and language therapy effective for post-stroke aphasia
535: Implementation tools developed by guideline producers may improve guideline uptake
534: Acupuncture effective in preventing tension-type headache
533: Limited evidence for benefits of short-course oral steroids for chronic rhinosinusitis
532: Behavioural treatment and pharmacotherapy effective for smoking cessation in people with COPD
531: Varenicline more effective for smoking cessation than bupropion
530: Daily iron supplementation beneficial in menstruating women
529: Limited evidence for benefits of interventions in preventing cold sores
528: Topical NSAIDs effective for pain in knee osteoarthritis
527: Vitamin supplementation does not prevent miscarriage
526: Treatment of first unprovoked seizure should be individualised
525: Similar outcomes for different follow-up strategies in early breast cancer
523: Midwife-led continuity models of care beneficial
522: Yoga of some benefit for asthma
521: Primary prevention reduces the risk of unintended adolescent pregnancies
520: Mixed evidence on interventions for improving outcomes in patients with multimorbidity
519: Limited benefit from non-steroidal anti-inflammatory drugs for chronic low back pain
518: Limited evidence for benefits of interventions to reduce sitting at work
517:Skin grafting and tissue replacement effective for diabetic foot ulcers
516: Legislative smoking bans improve health outcomes
515: Over the counter artificial tears effective for dry eye syndrome
514: Therapist-supported internet CBT effective for adult anxiety disorders
513: Limited evidence for effectiveness of home-based end-of-life care
512: Topical steroids effective for scalp psoriasis
511: Herpes zoster vaccine effective in older adults
510: Limited evidence for benefits of dietary fibre in cardiovascular disease
509: Motor control exercise similar to other forms of exercise for chronic non-specific low-back pain
508: Little evidence for water precautions in preventing infections in children with grommets
507: Limited evidence for benefits of tricyclics for nocturnal enuresis
506: Over-the-counter analgesics effective for acute postoperative pain
505: Limited evidence to support use of interactive telemedicine
504: Limited evidence for intra-articular corticosteroids in knee osteoarthritis
503: Limited evidence for light therapy as preventive treatment for seasonal affective disorder
502: Interventions to facilitate shared decision making reduce antibiotic prescribing
501: Two blood markers moderately accurate in screening for Down’s syndrome
500: Limited evidence for benefits of methylphenidate in ADHD
499: No identified risk in use of topical corticosteroids during pregnancy
498: Insufficient evidence for antihistamines for the common cold
497: Music improves sleep quality
496: No evidence for efficacy of NSAIDs for neuropathic pain
495: Presentation influences selection and consumption of food
494: Primary care consultation liaison effective for mental disorders
493: Crisis intervention effective in severe mental illness
491: Higher doses of atorvastatin reduce cholesterol more than lower doses
490: Pilates of some benefit for low back pain
489: Psychosocial interventions effective for smoking cessation in patients with coronary heart disease
488: Limited benefits from antivirals in Bell’s palsy
487: Rivastigmine has a small effect in Alzheimer’s disease
486: No benefit from treating asymptomatic bacteriuria
485: Psychological interventions may benefit non-specific chest pain management
484: Incentives effective for smoking cessation
483: Personalised care planning beneficial for adults with chronic or long-term health conditions
482: Chondroitin effective for osteoarthritis
481: CBT plus tapering dose reduces benzodiazepine use in short term
480: SSRIs and SNRIs ineffective for preventing tension-type headaches
479: Topical rubefacients ineffective for musculoskeletal pain
478: Uricosuric medications effective for chronic gout
477: CBT effective for medically unexplained physical symptoms
476: Case management beneficial for people with dementia
475: Topical anti-inflammatory agents effective for seborrhoeic dermatitis of the face or scalp
474: Effects of fixed-dose combination therapy for prevention of cardiovascular disease uncertain
473: Limited evidence for effectiveness of H1-antihistamines for chronic spontaneous urticaria
472: Alpha-blockers effective for ureteral stones
471: No specific treatment beneficial for painful nipples among breastfeeding women
461: Minimal benefits from neuraminidase inhibitors in influenza
460: Calcium channel blockers minimally effective for Raynaud’s phenomenon
459: No evidence for routine systemic antibiotics for venous leg ulcers
458: Psychosocial interventions may be of some benefit in prostate cancer
458: Limited benefit from hip protectors
457: Vitamin D alone ineffective for preventing fractures
457: Vitamin D supplementation may reduce mortality in elderly adults
456: Short-term psychodynamic psychotherapies can benefit common mental disorders
449: Powered toothbrushing more effective than manual for oral health
448: Ultrasound ineffective for chronic low-back pain
446: Self-management effective for chronic obstructive pulmonary disease
445: Electromagnetic field treatment effective for osteoarthritis pain
444: Water-based exercise training beneficial in chronic obstructive pulmonary disease
442: Decision aids helpful for treatment or screening conditions
Amoxicillin once or twice daily as effective as three times daily dosing for acute otitis media
Variety of interventions improve safety and effectiveness of medicines use
Statins ineffective for dementia
Sumatriptan effective for acute migraine in adults
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